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THE PHARMA REVIEW APRIL 06
Design and Evaluation of
Timed Release Matrix Suppositories of Indomethacin
S.Jayaprakash,
N.Jawahar, D.Dhachina Moorthi, S.Ramkanth, A.Mohamed Anzar, M.Nagarajan
Abstract: The practicals in undergraduate and postgraduate programmes are given the equal importance as that of theory examinations in pharmaceutical education. The practical examination comprises of various components such as Synopsis, Viva voce, major and minor experiments. Is the pattern of the practical examinations similar for all subjects? The practical examinations vary within different subjects of the same university and there is a wide variation between various universities. The practical part is also evaluated as per the outcome of experimental results. Are we evaluating the practicals correctly? This question is the need of the hour. There is a wide acceptance that the experimental skills such as handling the instruments, methodologies, planning etc. are not being considered for the evaluation. The vital components are not considered and the evaluation system encourages mainly the memory skills. The practical evaluation should comprise of the technical skills, planning and problem solving approaches to facilitate knowledge based learning. There is a need for measuring the practical skills accurately with its essential attributes. The above content is an abstract only. For the full Article please contact: |
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Abstract: Indomethacin, a classical anti-inflammatory drug was formulated as timed release matrix suppository adapting unconventional combinations of bases such as agar, polyethylene glycol-6000 (PEG-6000) and sodium carboxy methyl cellulose (SCMC) for better prolonged release and mainly to reduce severe gastric ulceration, bleeding and hepatotoxicity. The unconventional, non-melting, non-disintegrating suppositories were prepared using fusion method and studied for invitro release kinetics. The suppositories were also examined for physicochemical characteristics such as dimensions, homogeneity, crushing strength, drug content uniformity and stability. Among the various formulations, batch(I3) with agar (6%), PEG-6000 (4%) and SCMC (1.5%) showed excellent physicochemical characters and enhanced the drug release(91.34%) by following zero order kinetics and obeys Higuchi's equation.
