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THE PHARMA REVIEW APRIL 06
Development and Evaluation of
Membrane Controlled Transdermal Therapeutic Systems
Prasanna Sagar,
Raghavendra V Kulkarni and Hiremath Doddayya Abstract:
In the present study, membrane controlled transdermal therapeutic systems of
ethyl cellulose and poly(vinyl alcohol) containing an antihypertensive drug,
verapamil hydrochloride were developed by the method of casting on mercury
surface. An attempt has been made to enhance the skin permeation of drug
using three terpenes viz. cineole, d-limonene and citral (each at 10 %, 15 %
and 20 % w/w of polymer). The prepared formulations were subjected for
evaluation of thickness uniformity, drug content uniformity, skin
irritation, and in vitro drug permeation through excised mouse skin. Among
the three terpenes, cineole has shown the maximum enhancement in drug
permeation at 15 % (w/w of polymer). The permeation enhancement
characteristics of terpenes was in the order cineole > d-limonene > citral.
The formulations followed nearly zero order kinetics. Key words: Transdermal, verapamil hydrochloride, terpenes, skin permeation. The above content is an abstract only. For the full Article please contact: |
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