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THE PHARMA REVIEW APRIL 06
Natural Products: Leads for
Drug Discovery and Development
R. Sehgal, M.
Nandave and S. K. Ojha Abstract:
Bioactive natural products have an enormous economic importance as specialty
chemicals. Apart from drugs, they can also be used as lead compounds,
nutraceuticals, excipients, cosmetics etc. Natural products and leads from
terrestrial, microbial and marine sources have long served as sources of
therapeutic drugs that are used in medicine today. Structural diversity of
natural compounds makes them a very valuable source of novel lead compounds
against newly discovered therapeutic targets. More often, these natural
products provide lead structures that can serve as starting material for
chemical modification to derive an optimal drug. Indeed, majority of today's
major drugs have their origin in nature. Therefore, it is expected that the
study of chemistry and biology of natural products will make the process of
drug development more active and rewarding.The above content is an abstract only. For the full Article please contact: |
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