Formulation and Evaluation of the Fast Dissolving Tablets of Aceclofenac

R. Margret Chandira, B.S. Venkataeswarlu, M.V. Kumudhavalli, Debjit Bhowmik, Dr. B. Jayakar

Abstract: Aceclofenac is a novel NSAID used to relieve the pain and inflammation associated with Rheumatoid arthritis, Osteoarthritis and Ankylosingspondylitis. Fast dissolving tablets disintegrate or dissolve in saliva or swallowed without water. As the tablet disintegrates in mouth, this enhances the clinical effects of drug through absorption from mouth, pharynx and esophagus leading to an increase in bioavailability by avoiding first pass liver metabolism. In the present study solubility was enhanced by using beta cyclodextrins, sweeteners and flavors were used to enhance the organoleptic properties of tablets. Fast dissolving tablets of Aceclofenac were prepared by direct compression by super disintegrants such as L-HPC, Crospovidone and S.S.G in different concentrations.All the formulations were evaluated for the influence of disintegrates and their concentrations on the characteristics of Fast dissolving tablets mainly in terms of disintegration time and dissolution studies. Tablets containing Crospovidone at 10% concentration showed 26 sec disintegration time and 93% of drug is release in 4 min. Tablets containing L-H.P.C AT 10% showed 35 sec.disintegration time and 98% of drug release in 2 min. The tablets were also evaluated for its hardness, friability and other parameters. All parameters complied with I.P. limits.
Fast dissolving tablets are not only indicated for people who have swallowing difficulties, but also are ideal for active people. Fast dissolving tablets are also called as mouth-dissolving tablets, melt-in mouth tablets, Orodispersible tablets, rapimelts, porous tablets, quick dissolving etc. Fast dissolving tablets are those when put on tongue disintegrate instantaneously releasing the drug which dissolve or disperses in the saliva. The faster the drug into solution, quicker the absorption and onset of clinical effect. Aceclofenac is a novel NSAID used to relieve the pain and inflammatioassociated with Rheumatoid arthritis, Osteoarthritis and Ankylosingspondylitis.
The aim & objective of present study is Aceclofenac was chosen as a drug candidate, since it is widely prescribed drug especially in elderly patients to relieve pain and inflammation associated with rheumatoid arthritis. This fast dissolving dosage forms will be better accepted by the patients(geriatric).Hence it was felt that prudent to formulate the drug into fast dissolving tablet to improve market segment with novel drug delivery system, the fast dissolving technology was selected. To objective of current study is To enhance the drug absorption, To mask the bitter taste of the drug.


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