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THE PHARMA REVIEW (DECEMBER 2008)

Nanosuspensions - An Emerging Carrier for Delivery of Bioactive Agents

N. Rama Rao, Prasanthi N.L., R. Ramakrishna and K. Babu Nageswararao

Abstract: In recent years, there has been a considerable interest in the development of novel drug delivery systems using particulate delivery systems like nanoparticles. Nanoparticles represent a promising drug delivery system of controlled and targeted release. In this context, nanosuspensions will be effective in increasing the solubility, bioavailability of poorly soluble drugs. The review focuses on advantages, method of preparation, physical characteristics and evaluation of nanosuspensions.
 
Introduction
A large proportion of new chemical entities coming from drug discovery are water insoluble, and therefore poorly bioavailable, leading to hurdles in formulation development efforts. There are number of formulation approaches like micronisation, solubilization using cosolvents, precipitation techniques etc., to resolve the problems of low solubility and low bioavailability. Each of them have their own limitations. Other techniques like micro emulsions, solid dispersions and inclusion complexes using cyclodextrins even though showed increased solubility, but not applicable for drugs which are insoluble in both aqueous and organic media. The next development stepis transformation of the micronized drug to drug nanoparticles and nanosuspensions. Nanoparticulate drug delivery system may offer plenty of advantages over conventional dosage forms which include improved efficacy, reduced toxicity, enhanced biodistribution and improved patient compliance. Nanosuspension technology offers novel solution for these poorly soluble drugs. Nanosuspension consists of pure poorly water soluble drugs with or without any matrix material suspended in dispersion. They can be surfactant free; can also comprise surfactants or stabilizers or both. Nanosuspensions differ from nanoparticles, which are polymeric colloidal carriers of drugs (Nanospheres and nanocapsules), and from solid-lipid nanoparticles (SLN), which are lipidic carriers of drug.

 

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