|
Abstract: In recent years, there has been a
considerable interest in the development of novel drug
delivery systems using particulate delivery systems like
nanoparticles. Nanoparticles represent a promising drug
delivery system of controlled and targeted release. In
this context, nanosuspensions will be effective in
increasing the solubility, bioavailability of poorly
soluble drugs. The review focuses on advantages, method
of preparation, physical characteristics and evaluation
of nanosuspensions.
Introduction
A large proportion of new chemical entities coming from
drug discovery are water insoluble, and therefore poorly
bioavailable, leading to hurdles in formulation
development efforts. There are number of formulation
approaches like micronisation, solubilization using
cosolvents, precipitation techniques etc., to resolve
the problems of low solubility and low bioavailability.
Each of them have their own limitations. Other
techniques like micro emulsions, solid dispersions and
inclusion complexes using cyclodextrins even though
showed increased solubility, but not applicable for
drugs which are insoluble in both aqueous and organic
media. The next development stepis transformation of the
micronized drug to drug nanoparticles and
nanosuspensions. Nanoparticulate drug delivery system
may offer plenty of advantages over conventional dosage
forms which include improved efficacy, reduced toxicity,
enhanced biodistribution and improved patient
compliance. Nanosuspension technology offers novel
solution for these poorly soluble drugs. Nanosuspension
consists of pure poorly water soluble drugs with or
without any matrix material suspended in dispersion.
They can be surfactant free; can also comprise
surfactants or stabilizers or both. Nanosuspensions
differ from nanoparticles, which are polymeric colloidal
carriers of drugs (Nanospheres and nanocapsules), and
from solid-lipid nanoparticles (SLN), which are lipidic
carriers of drug.
For full text of this article contact the publisher on
info@kppub.com
|
The above content is an
abstract only. For the full Article please contact:
KONGPOSH Publications Pvt. Ltd.
ICS House, C-19, Commercial Complex, SDA, Opp. IIT Gate,
New Delhi, India -110016
Tel.: 26855839, 20057149, Fax: 91-11-26855876
Email:
info@kppub.com /
fpc@vsnl.com, Website:
http://www.kppub.com |
