Polymeric Ocular Drug Delivery System for Controlled Release of Ofloxacin: In Vitro and In Vivo Characterization

Abstract: Ocular films of ofloxacin were prepared with the objectives of reducing the frequency of administration, to improve patient compliance, obtaining controlled release and greater therapeutic efficacy in the treatment of eye infections such as blepharo-conjunctivitis, kerato-conjunctivitis, keratitis, corneal ulcers etc. HPMC-ofloxacin matrices were prepared by mercury substrate method. The influence of rate controlling membrane of different polymers (ethyl cellulose, eduragit RL100 and RS100) on release kinetics was studied. These ocular films were evaluated for physico-chemical characteristics. The prepared films were found to be flexible and transparent. The average weight and thickness of were found to be 6.4-11.3 mg and 48.4-87.5 microns, respectively. The drug content varied from 99.2-104.6%. The exposure to UV radiations sterilized the ocular films and no microbial growth was observed in any formulation in sterility testing by direct inoculation method. The formulations were subjected to in vitro and in vivo release studies. OF-3 with rate controlling membrane of eduragit RS100 followed perfect zero order release kinetics. In vivo studies carried out in the eyes of rabbits showed controlled release upto 24 hours. There was a good correlation between the in vitro and in vivo data.

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