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THE PHARMA REVIEW
FEBRUARY 06
Formulation and Evaluation of
Cefadroxil Dispersible Tablets
S. T. Bhagawati*, S. M.
Hiremath1 and S. A. Sreenivas
Abstract: Cefadroxil, a first generation cephalosporin has a wide antibacterial spectrum being effective against both gram positive and negative bacteria. The drug is well absorbed after taken orally. Major problem with this drug is its plasma half life 1 to 1.5 hours. Therefore, tablet formulation of cefadroxil with various disintegrants like croscarmellose sodium, crospovidone and sodium starch glycolate was prepared with a view to increase its solubility and bioavailability. Among the three disintegrants added, the tablets prepared with croscarmellose sodium are superior with respect to disintegration and dissolution characteristics. All formulations were subjected for kinetic analysis; results indicated that all the formulations prepared follows first order release rate kinetics with CF1 having good correlation coefficient of 0.9981. The dissolution profile of promising batch CF1 was compared with marketed preparation. The marketed preparation showed 93.72% (R2 0.9941) of drug release after 15 minutes where as CF1 showed 100.08% of drug release. CF1 was also subjected for stability studies and was found to be stable for 4 weeks at 450 c with insignificant change in disintegration time and in vitro drug release pattern. The above content is an abstract only. For the full Article please contact: |
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