Determination of Cefadroxil in Bulk Powder and its Dosage Forms by Spectrophotometric Method

Abstract: A simple and sensitive spectrophotometric method has been developed for determination of cefadroxil in bulk powder and its pharmaceutical dosage forms. The proposed method was based on reaction of primary amine group of cefadroxil and acetyl acetone-formaldehyde reagent, which gives a yellow coloured chromogen with absorption maxima at 400.0nm. The method is found to be linear in the concentration range of 20 - 100µg/ml with regression co-efficient of 0.9998. No significant difference was found between proposed and official method when one and two tailed t-test were applied. Various reaction parameters (reagent concentration and time for maximum colour development, effect of temperature on reaction and effect of pH of reagent) were optimized. The method was validated and can be used successfully to assay cefadroxil in bulk powder and its pharmaceutical dosage forms i.e. tablets and capsules.

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