Role of Chelation in Malignancy

Abstract: Trace quantities of several metals are essential constituents of the human body. This is because the activity of many enzymes depends on these metal ions. Though the amount of metals present in human body is approximately 0.3% of the body weight, but excess of any metal is harmful to the body. With industrial and technological advancements, metal pollution in the atmosphere has been increasing fast. Excess concentration of trace metals gradually accumulates in the body, leading to metal induced toxicity. One of the major toxicity induced by these metals is their ability to behave as carcinogens. Chelation is helpful in malignancy by two main ways namely, as cytotoxic drugs and as radioactive agents in imaging studies. This review is an attempt to comply the use of chelates as cytotoxic drugs and as radioactive agents in imaging studies. It also covers the latest advancement in use of chelates conjugated with monoclonal antibodies as radioactive agents in imaging studies.

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