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THE PHARMA REVIEW OCTOBER 2006

Formulation and Evaluation of Gentamicin Sulphate Ocuserts

S. Jayaprakash, D. Dhachinamoorthi, S. Ramkanth, M. Nagarajan, K. Sangeetha

Abstract: Gentamicin sulphate ocuserts were prepared using different polymers such as hydroxypropylmethylcellulose (HPMC), methylcellulose (MC), Polyvinylpyrrolidone (PVP), Ethylcellulose (EC), and Microcrystallinecellulose (MCC), at different concentrations and combinations. The ocuserts were prepared by using solvent casting technique. The prepared ocuserts were evaluated for moisture absorption, moisture loss, thickness, weight variation and drug content. The in vitro release of drug from the formulations was studied using commercial semi permeable membrane. A zero order release Formulation F6 was sterilized by ethylene oxide and subjected to in vivo studies. IR spectral observations show there is no interaction with polymer. It indicates the intactness of the drug in formulation.

 
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