Abstract: Titrimetric method for estimation of poorly water-soluble drugs like frusemide, ketoprofen, aceclofenac has been developed. In the present investigation, hydrotropic solubilization technique has been employed to solubilize the poorly water-soluble anti-inflammatory drugs ibuprofen and flurbiprofen by 0.5M ibuprofen sodium solution for their titrimetic analysis. The proposed method is new, simple, economic and safe. The results of the method have been compared with the Indian Pharmacopoeial method and validated statistically for accuracy, reproducibility and precision.
Introduction
Hydrotropy is a solubilization phenomenon where by addition of large amount of a second solute results in increase in the aqueous solubility of another solute. It is one of the various techniques employed to enhance the aqueous solubility of poorly water-soluble drugs. Most popular hydrotropic agents sodium benzoate, sodium salicylate, sodium acetate, sodium ascorbate, sodium citrate and urea, have been employed to enhance the aqueous solubility of many poorly water-soluble drugs. Maheshwari analysed various poorly water-soluble drugs, using hydrotropic solubilization phenomenon viz. cefixime, frusemide, ketoprofen, salicylic acid, tinidazole and aceclofenac. Maheshwari et al. have developed various analytical techniques employing hydrotropic solubilization phenomenon, to analyze poorly water-soluble drugs, hydrochlorothiazide, aceclofenac and ofloxacin.
There was more than 75 and 105 fold enhancement in the solubilities of ibuprofen and flurbiprofen, respectively as compared to their water solubilities.Therefore it was thought worthwhile to solubilize these drugs in 0.5 M ibuprofen sodium solution to carry out titrimetric analysis.
For the purpose of titrimetric estimation usually various organic solvents like methanol, alcohol, acetone and dimethylformamide are employed to solubilize poorly water-soluble drugs. The former suffer from several drawbacks such as high cost, pollution and toxicity. The primary objective of this study was to employ hydrotropic solubilizing agent ibuprofen sodium solution for the selected model drugs to preclude the use of organic solvents.
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