Abstract: The present work aims at study of release pattern of two drugs ciprofloxacin hydrochloride, which is water-soluble, and nimesulide which is water insoluble in nature, from the buccal films using same polymer HPMC in association with PEG 400. These were compared so as to find out the importance of drug's solubility profile from the formulation into buccal mucosa for absorption. Investigation showed that mucoadhesive patches are promising drug delivery system if we keep the solubility profile of drug as the utmost consideration. The films exhibited satisfactory physical and mechanical properties. The release could be sustained from these patches for up to 7 hrs.
Introduction
“Ciprofloxacin Hydrochloride is a potent, first generation, water soluble, broad spectrum fluoroquinolone derivative, commonly used in urinary tract infections, gonorrhoea, chancroid, typhoid; gynaec wound infections, tuberculosis, respiratory infections, meningitis, conjunctivitis etc. It possesses narrow therapeutic index with a half-life of 3-8 hr. A sustained release formulation of ciprofloxacin hydrochloride would help to prolong the effect of the drug and will also avoid its side effects like nausea, headache, vomiting, anorexia, insomnia, dizziness etc. Nimesulide (NS) is a water insoluble, sulfonamide derivative NSAID having analgesic, antipyretic and anti inflammatory activity with a half life of 2-4 hr. To reduce its major side effect of gastric irritation, buccal delivery dosage form was formulated. The present study would not only improve the efficiency of therapy and patient compliance but also reduces the adversaries of therapy.
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