Abstract: Treatment of central nervous system (CNS) disorders is the greatest challenge and largest potential growth sector of the pharmaceutical industries. But, 100% of large molecule drugs and more than 98% of small molecule drugs do not cross the blood-brain barrier (BBB). The brain is a delicate organ, and evolution built very efficient ways to protect it. The same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. This article discusses the potentials of intranasal drug delivery for direct nose-to-CNS transport of drugs, underscores mechanisms of trans-nasal transport, and various physico-chemical factors that can influence the transport of drugs to the CNS.
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