Analgesic Activity of Ammomum Subulatum Fruit Extract

Khursheed Alam, Devender Pathak, Shahid H. Ansari

Abstract: The present study was designed to investigate the analgesic activity of Ammomum subulatum (Family - Zingiberaceae) fruit extract using acetic acid induced writhing test and Eddy’s hot plate method. Ethanolic extract of Ammomum subulatum fruit showed significant (P < 0.001) reduction in the number of writhing induced by acetic acid and increased in reaction time in hot plate test.

Ammomum subulatum (Family - Zingiberaceae) is a tall, perennial plant, with leafy stems, up to 2.5 m in height, leaves oblong-lanceolate, acuminate, glabrous; spikes globose, very dense, shortly peduncled;1 Cultivated in swampy places in Bengal, Sikkim, Assam and Tamil Nadu,2 fruit is large, coarsely striated dark brown in colour, measuring 2-3 cm in length and upto 1.5 cm in width. It is a trilocular capsule, anterio-posteriorly flattened, having a number of irregular, dentate- undulate wings which extend from the apex downwards for two third of its length. Internally, the capsule contains several seeds held together by a viscous pulp of dark brown colour.3 Oil extracted from the seeds is aromatic, stimulant, stomachic, applied to eyelids to allay inflammation.4 Decoction of seeds is used as a gargle in affections of the teeth and gums. In combination with the seeds of melon it is used as a diuretic in cases of gravel of the kidneys.5 Seeds are also used in gonorrhea and as an aphrodisiac. They have been also found useful in neuralgia in large doses.6


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