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Abstract: Advancements in active
drug-delivery technologies hold promise for precisely
controlled targeted treatments. To get effectively from
point A to point B, you need a safe and reliable mode of
transportation. If your brakes are shot or your radiator
is on the fritz, a faulty vehicle can break down and
leave you stranded on the side of the road. Likewise,
drug-delivery devices are the vehicles ensuring that
critical treatments safely reach their destinations and
their reliability is equally important. Because if these
delivery systems fail, you may find yourself in a dire
situation. Luckily, drug-delivery technology appears to
be advancing at a rapid clip. Controlled-release drug
delivery systems have many applications, including
treatments for hormone deficiencies and chronic pain. A
biodegradable device that could provide multi-dose drug
delivery would be advantageous for long-term treatment
of conditions requiring pulsatile drug release. A
microchip that has the ability to store a large number
of drugs or chemicals, control the time at which release
begins, and control the rate at which the chemicals are
released. The microchip could be integrated with a tiny
power supply and controlled by a microprocessor, remote
control, or biosensors. This microchip technology has
potential uses in areas such as medical diagnostics,
chemical detection, combinatorial chemistry, drug
delivery and cosmetics.
Introduction: Much research has been
ongoing in the quest to find an ideal system for drug
delivery within the human body. Drug delivery is a very
important aspect of medical treatment. The effectiveness
of many drugs is directly related to the way in which
they are administered. Unfortunately, this can make it
very difficult to select the proper drug delivery
system. Some therapies require the drug to be repeatedly
administered to the patient over a long period of time,
in specific amounts at a time in order to maximize drug
effectiveness. In many cases, patients often forget, or
are unwilling, or are unable to take their medication.
Furthermore, some drugs are too potent for systemic drug
delivery and cause more harm than good. Therefore, it is
of a great advantage to find a drug delivery device that
is capable of controlled, pulsatile or continuous
release of a wide variety of drugs that can be safely
implanted inside the body. Biocompatability, material
reliability, method of drug release, and processibility,
are only a few of the many significant factors that need
to be considered in creating a successful and effective
drug delivery system of this type.
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