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THE PHARMA REVIEW (JAN 2010)

Injecting New Ideas Into Drug-Delivery Systems-A Brief Review on Microchips as Controlled Drug-Delivery System

Viral Shah, Kruti Patel, U.M. Upadhyay

Abstract: Advancements in active drug-delivery technologies hold promise for precisely controlled targeted treatments. To get effectively from point A to point B, you need a safe and reliable mode of transportation. If your brakes are shot or your radiator is on the fritz, a faulty vehicle can break down and leave you stranded on the side of the road. Likewise, drug-delivery devices are the vehicles ensuring that critical treatments safely reach their destinations and their reliability is equally important. Because if these delivery systems fail, you may find yourself in a dire situation. Luckily, drug-delivery technology appears to be advancing at a rapid clip. Controlled-release drug delivery systems have many applications, including treatments for hormone deficiencies and chronic pain. A biodegradable device that could provide multi-dose drug delivery would be advantageous for long-term treatment of conditions requiring pulsatile drug release. A microchip that has the ability to store a large number of drugs or chemicals, control the time at which release begins, and control the rate at which the chemicals are released. The microchip could be integrated with a tiny power supply and controlled by a microprocessor, remote control, or biosensors. This microchip technology has potential uses in areas such as medical diagnostics, chemical detection, combinatorial chemistry, drug delivery and cosmetics.

Introduction: Much research has been ongoing in the quest to find an ideal system for drug delivery within the human body. Drug delivery is a very important aspect of medical treatment. The effectiveness of many drugs is directly related to the way in which they are administered. Unfortunately, this can make it very difficult to select the proper drug delivery system. Some therapies require the drug to be repeatedly administered to the patient over a long period of time, in specific amounts at a time in order to maximize drug effectiveness. In many cases, patients often forget, or are unwilling, or are unable to take their medication. Furthermore, some drugs are too potent for systemic drug delivery and cause more harm than good. Therefore, it is of a great advantage to find a drug delivery device that is capable of controlled, pulsatile or continuous release of a wide variety of drugs that can be safely implanted inside the body. Biocompatability, material reliability, method of drug release, and processibility, are only a few of the many significant factors that need to be considered in creating a successful and effective drug delivery system of this type. 

 

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