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THE PHARMA REVIEW (JANUARY - FEBRUARY 2011)

Formulation Technologies for Development of Oral Dispersible Tablets

Yash Paul, Sarvan Tyagi, Bhupinder Singh

Abstract: Despite of tremendous advancements in drug delivery, the oral route still remains the preferred route of administration of therapeutic agents because of low cost of therapy and ease of administration. Recent developments in technology have encouraged scientists to develop oral dispersible tablets (ODT) with improved patient compliance and convenience with enhanced bioavailability. ODT are solid dosage form containing medicinal substance(s) which disintegrate rapidly, usually a matter of seconds, when placed on tongue. ODTs are advantageous particularly for pediatric and geriatric patients who have difficulty in swallowing conventional tablet and capsules. This review describes formulation aspects of ODTs, challenges to develop ODTs, marketed formulations and drug explored in this field.
Introduction: Over the past one decade, there has been an enhanced demand for more patient-friendly and compliant dosage forms. As a result, the demand for developing new technologies has been increasing 1. Since the development cost of a new drug molecule is very high, efforts are now being made to focus on the development of new drug dosage forms for existing drugs with improved safety and efficacy, bioavailability together with reduced dosing frequency, and the production of more costeffective dosage forms. Oral dispersible tablets offer advantage for patients who have difficulty in swallowing. It has been reported that disphagia1 (difficulty in swallowing) is common among all age groups of patients but is more specific to pediatrics, geriatrics along with institutionalized patients and patients with nausea, vomiting and motion sickness complications2. ODTs with good taste and flavor increase the acceptability of bitter drugs by various groups of population. Orally disintegrating tablets are also called as orodispersible tablets, quick disintegrating tablets, mouth dissolving tablets, fast disintegrating tablets, fast dissolving tablets, rapid dissolving tablets, porous tablets, and rapimelts. However, of all the above terms, United States pharmacopoeia (USP) approved these dosage forms as ODTs. Recently, European Pharmacopoeia has used the term orodispersible tablet for tablets that To fulfill these medical needs, pharmaceutical technologists have developed a novel oral dosage form known as Orally Disintegrating Tablets (ODTs) which disintegrate rapidly in saliva, usually in a matter of seconds, without the need to take it with water. Drug dissolution and absorption as well as onset of clinical effect and drug bioavailability may be significantly greater than those observed from conventional dosage forms.

 

 

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