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THE PHARMA REVIEW (JANUARY - FEBRUARY 2011)

Medicinal Plants of Wound Healing Potential in Diabetic Condition – A Review

Roopashree T.S, Raman Dang, Shobha Rani R.H, Narendra C

Abstract: Wound healing occupies an important and developing field of research in modern biomedical sciences. As such the process of wound healing is highly complicated and becomes more complex when associated with conditions like diabetics, which itself is a substantial socioeconomic and quite serious life burden. As a consequence of its chronic complications, wound healing in diabetic condition continues to be a therapeutic challenge. Chronic wounds afflict a very large number of patients and seriously reduce their quality of life. With the rising elderly population and the increasing incidence of diabetes, the care of these wounds is fast becoming a billion-dollar business. Treatments that exist today, however, are often expensive and exhibit major adverse effects. Scientists who are trying to develop newer drugs for diabetic wound care are looking toward the Natural sources. In the Indian traditional system of medicine several drugs of plant, mineral, and animal origin are described for their wound healing properties. Most of these drugs are derived from plant origin. This paper reviews the accumulated literature for some Indian herbs with their recent advancement in treating chronic wounds in diabetic condition.
Introduction
Diabetes mellitus is one of the major contributors to chronic wound healing problems. When diabetic patients develop an ulcer, they become at high risk for major complications, including infection and amputation. The pathophysiologic relationship between diabetes and impaired healing is complex. Vascular, neuropathic, immune function and biochemical abnormalities each contribute to the altered tissue repair. Despite treatment of these chronic wounds, which involves tight glucose control and meticulous wound care, the prognosis for their healing is quite poor.
It has been suggested that diabetes impairs wound healing through disruption of local cytokine production, notably platelet derived growth factor (PDGF), tumor necrosis factor α (TNFα), interleukin-1β, and vascular endothelial growth factor (VEGF), reduced biosynthesis and or accelerated degradation of newly synthesized collagen. These qualitative and quantitative abnormalities contribute to the impaired wound healing observed in diabetes.
There are very few Indian studies on the epidemiology of chronic wounds. In one study, the prevalence of chronic wounds in the community was reported as 4.5 per 1000 population where as that of acute wounds was nearly doubled at 10.5 per 1000 population. An untreated wound in diabetic patients leads to infection and which may become incurable leading to amputation of the affected part of the body in order to prevent the infection to other parts of the body. It has been reported that diabetes is the cause of almost 50% of all nontraumatic lower-extremity amputations worldwide. It is estimated that the lifetime risk for amputation in patients with diabetes is 10–15%.

 

 

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