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THE PHARMA REVIEW (JANUARY - FEBRUARY 2011)

Protective Effect of Aqueous Fraction of Prunus Persica L Aqueous Extracton Acute Inflammation in Rats

Lokesh Deb, Ravi Gupta, Debjit Bhowmik, A.S. Dutta, K.P. Sampath Kumar

Abstract: Prunus persica L widely distributed in Manipur, India. The leaves were used in folklore/traditional medicine to treat several inflammatory pathologies such as greenish swelling (gland), oedema etc. Reactive oxygen species as well as reactive free radicals such as hydroxyl (OH), nitric oxide (NO) etc. contribute significantly to these pathologies. To determine the acute toxicity (LD50) of different products like aqueous extract of Prunus persica L. To evaluate the anti-inflammatory activity of aqueous extract of Prunus persica L leaves on albino rats.
Introduction: The use of plants and plant extracts for medicinal purposes has been going on for thousands of years. Herbarium and folk medicine both ancient and modern have been the source of much useful therapy. Some of the plant products currently used either in their natural form or as derivatives, were often used originally for other purposes, such as arrow poisons, as part of religious or other rituals and even as cosmetics. An examples of such products includes Opium, Belladona, Cinchona bark, Ergot, Curare, Nutmeg, Colaber beans, Foxglove etc.The earliest mention of medicinal use of plants found in RIG VEDA oldest repository of the human knowledge, having been written about 4000B.C. (Chopra, 1958). Sushrutta samhita written earlier than 1000B.C. contains very comprehensive notes on therapeutics. Charka samhita gives remarkable materia medica of ancient Hindus.The plant kingdom represents an extraordinary reservoir of novel molecules of estimatied 4,00000-5,00000 plant speices around the globe, only a small percentage of which have been chemically investigated to isolate and identify secondary plant constituent. The vast majority of these secondary compounds are not essential for the normal physiology of plant growth and reproduction. With this background in present study we thought of finding a remedy available at a hand‘s stretch for the treatment and management of inflammatory response. In addition to this there is a global trend to revive the traditional systems of medicine. In the globalization and post- GATT scenario the cost of allopathic medicines is escalating. The side effects associated with various allopathic drugs are also the cause for renewed interest in traditional systems of medicine. In this background we thought to find out effective safer and cheaper remedy for inflammatory disorders at a hands stretch. In this connection we had undertaken field surveys and contact programmes with native practitioners of Manipur to explore the possibilities of using locally available herbs for the purpose. In two of our field surveys we found a plant Prunus persica L, and native practitioners were claimed that it is highly useful in treating inflammatory disorders. In our present study used animal model to evaluate Prunus persica L.The Carageenan induced inflammation is a useful model to detect oral action of anti-inflammatory agents. The development of carrageenin induced edema is believed to be biphasic of which the first phase is mediated by release of histamine, seritonin, and kinins in the first hour after injection of carrageenan and the second phase is related to release of prostaglandin like substances in 2-3 hours.

 

 

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