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THE PHARMA REVIEW (JANUARY - FEBRUARY 2011)

Screening of Antioxidant Activity of Alcoholic Root Extract of Calotropis Gigantea R. Br.

Abhishek Dwivedi, Ameeta Argal

Abstract: Calotropis gigantea has been successfully used in Indian system of medicine for the treatment of various ailments. Hence its roots were studied for antioxidant activity for validation.
Antioxidants are believed to quench free radicals which are unpaired and free electron making them highly reactive. Oxidative free radicals are generated by metabolic reactions creating a chain reaction leading to membrane and other lipid peroxidation, DNA damage, etc. The antioxidants interact with the free radicals and stabilize them. One major action of antioxidants in cells is to prevent damage due to the action of reactive oxygen species like hydrogen peroxide (H2O2), the superoxide ion (O2−), and free radical such as the hydroxyl ion (·OH). They may be enzymatic like the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase or non enzymatic like β- carotene, α- tocopherol and ascorbic acid.
Flavonoids have shown to have antioxidant activity. In conjugation with Vitamin C and E they inhibit lipid peroxidation. They may trap chain initiating radical at the interface of membrane thus preventing the progression of the radical chain reaction1-2.
Material and Methods Plant material
The plant parts of C. gigantea were authenticated by National Herbarium of Cultivated Plants, New Delhi, voucher no. NHCP/NBPGR/2005/89/4072. The roots were collected in April from Bhopal (M.P.). The peeled roots were dried in shade, coarsely powdered and extracted with 95% alcohol..

 

 

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