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THE PHARMA REVIEW
(JULY 2009) |
D-Pinitol – Insulomimetic –
A New Hope for Management of Type-2 Diabetes Mellitus
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O.P. Gupta, Pavan Malhotra,
Archana Parihar, Shakti Bala and Geetika Gupta |
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Abstract: D-pinitol (3-O-methyl chiroinositol),
an active principle was first discovered from the leaves
of Bougainvillea spectabilis. These leaves traditionally
being used for various diabetes associated conditions.
Later, D-pinitol was found to be present in a number of
other plants also. Studies carried out in animals and in
human have shown that D-pinitol lowers the blood glucose
level and improves utilization of glucose by tissues
i.e. it mimics insulin action. D-pinitol gets converted
to D-chiroinositol (DCI) in the body. DCI contain
phosphoglycans which are known to mediate the action of
insulin. Evidently, the insulin like action of D-pinitol
is being mediated by the phosphoglycans of DCI. Thus, D-pinitol
has the potential to be used as food supplement in
patients of diabetes for the effective management of the
disease. An important observation made by the authors of
this paper while studying the activity of the fraction
of a plant was neogenesis of the beta cells of the
pancreas. The active principle of the said fraction was
fraction was found to be D-pinitol.
Introduction
The leaves of Bougainvillea spectabilis used in
traditional system of medicine for conditions associated
with diabetes were found to cause hypoglycaemic effect
when fed to normal and diabetic mice by Narayanan et
al.1 Later, the chemical analysis was conducted and it
was found that D-pinitol was the active principle
involved for the production of hypoglycaemic effect.
Originally discovered in pine stumps, D-pinitol is now
reported to be present in a number of leguminous plants
including soy. Studies carried out at pre-clinical and
clinical levels with D-pinitol have shown that this
possesses insulin like activity. It has been stated that
“of all the proposed so called insulomimetics and
insulin co-factors, pinitol is the one with most
promise”. The effectiveness of D-pinitol has been
recorded be leading researchers has been awarded two
U.S. patents (5,550,166 and 5,827,896). D-pinitol has
been also reported to drive creatine and other nutrients
into muscle cells and thereby lead to faster muscle
growth and greater physical strength.
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