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Abstract: The main objective of the present study
was to develop matrix-moderated transdermal systems of
Glipizide and to evaluate them with respect to various
in vitro parameters. The matrix-type transdermal systems
were prepared using a drug with Ficus carica fruit
mucilage by the solvent evaporation technique. Drug and
mucilage interaction studies were performed. The patches
were subjected to various physicochemical studies, in
vitro release studies, permeation studies and skin
irritation studies. Transdermal patches of Glipizide
with Ficus carica fruit mucilage were prepared by the
solvent evaporation technique. The prepared patches
possessed satisfactory physicochemical characteristics.
Thickness, mass and drug content were uniform in
prepared batches. In vitro permeation studies were
performed using a Keshary-Chien diffusion cell across
hairless Albino rat skin. The non-ionic surfactants Span
80 was used as permeability enhancer. The non-ionic
surfactants in the patches increased the permeation
rate, Span 80 exhibiting better enhancement relative
other non-ionic surfactants. The patches were seemingly
free of potentially hazardous skin irritation. The best
patch among the formulations was selected for further in
vivo studies. Hence, it can be concluded that Glipizide
can be developed as a transdermal delivery system with
Ficus carica fruit juice that is an alternative to
intravenous administration and has minimal adverse
effects. In vitro permeation studies were performed
using rat abdominal skin as the permeating membrane in
Keshary-Chien cell.
Introduction
Glipizide, an effective antidiabetic drug that requires
controlled release owing to its short biological
half-life of 3.4 ± 0.7 hours,15 was used as the core in
transdermal matrix patches. The transdermal patches were
evaluated in vitro and in vivo methods for controlled
release. Various experimental reports indicated that
Glipizide as a good candidate for controlled release
formulation. Few controlled release formulations of
Glipizide (30, 60 mg) are also available commercially.
In this study, Ficus carica fruit mucilage was used as a
matrix polymer for controlling release of Glipizide.
Materials and Methods
Materials: Glipizide was obtained as a gift sample from
Dr Reddy’s laboratories, Hyderabad. Ficus carica fruits
were obtained from the main market of Anantapur and
authenticated by the Botany department of Sri
Krishnadevaraya University, Anantapur. Glycerin,
Propylene glycol Methyl paraben, Propyl paraben, Span-80
procured from S.D. Fine chemicals Mumbai. All the
reagents used were of AR grade. The drug samples were
characterized by means of UV spectrophotometric method
along with determination of solubility and pH for their
authentication.
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