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THE PHARMA REVIEW (JULY 2009)

Permeation Studies of Glipizide From Ficus Carica Fruit Mucilage Matrices for Transdermal Delivery

Dr. Y.Padmanabha Reddy, Hindustan Abdul Ahad, J. Sreeramulu, V. Hima bindu

Abstract: The main objective of the present study was to develop matrix-moderated transdermal systems of Glipizide and to evaluate them with respect to various in vitro parameters. The matrix-type transdermal systems were prepared using a drug with Ficus carica fruit mucilage by the solvent evaporation technique. Drug and mucilage interaction studies were performed. The patches were subjected to various physicochemical studies, in vitro release studies, permeation studies and skin irritation studies. Transdermal patches of Glipizide with Ficus carica fruit mucilage were prepared by the solvent evaporation technique. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. In vitro permeation studies were performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. The non-ionic surfactants Span 80 was used as permeability enhancer. The non-ionic surfactants in the patches increased the permeation rate, Span 80 exhibiting better enhancement relative other non-ionic surfactants. The patches were seemingly free of potentially hazardous skin irritation. The best patch among the formulations was selected for further in vivo studies. Hence, it can be concluded that Glipizide can be developed as a transdermal delivery system with Ficus carica fruit juice that is an alternative to intravenous administration and has minimal adverse effects. In vitro permeation studies were performed using rat abdominal skin as the permeating membrane in Keshary-Chien cell.

Introduction
Glipizide, an effective antidiabetic drug that requires controlled release owing to its short biological half-life of 3.4 0.7 hours,15 was used as the core in transdermal matrix patches. The transdermal patches were evaluated in vitro and in vivo methods for controlled release. Various experimental reports indicated that Glipizide as a good candidate for controlled release formulation. Few controlled release formulations of Glipizide (30, 60 mg) are also available commercially. In this study, Ficus carica fruit mucilage was used as a matrix polymer for controlling release of Glipizide.

Materials and Methods
Materials: Glipizide was obtained as a gift sample from Dr Reddy’s laboratories, Hyderabad. Ficus carica fruits were obtained from the main market of Anantapur and authenticated by the Botany department of Sri Krishnadevaraya University, Anantapur. Glycerin, Propylene glycol Methyl paraben, Propyl paraben, Span-80 procured from S.D. Fine chemicals Mumbai. All the reagents used were of AR grade. The drug samples were characterized by means of UV spectrophotometric method along with determination of solubility and pH for their authentication.

 

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