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THE PHARMA REVIEW (JULY 2009)

Urea Stibamine – The First Allopathic Drug Discovered in India

V. K. Kapoor

Kala-azar or visceral leischamaniasis is a protozoal disease by Leishmania donovani. The word kala-azar is derived from kala meaning black and azar meaning disease as it is associated with bronzing of the skin. According to Indian Council of Medical Research Kala-azar is a potentially fatal disease which affects nearly 350 million people in 88 countries across five continents and around 90 per cent of the victims are from the Indian subcontinent.* The treatment of the disease with modern drugs miltefosine and amphotericin-B cost anything between 50 to 150 US dollars for the entire course, which is unaffordable by the larger section of those who suffer from the disease.
 
Antimonial compounds have been used for the therapy of leishmaniasis but lost favour of clinicians due to their toxicity and side effects. The discovery of first category antimonial drugs for kala-azar was made in India at Campbell Medical School, Calcutta

  

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