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Abstract
Convenience of administration and patient compliance are
gaining significant importance in the design of drug
delivery systems. The present work includes formulation
of patient friendly antacids jellies to treat
oesophageal reflux in hiatus hernia and secondly design
of a novel model for evaluating in vitro residence time
of the formulations.
The jelly base was prepared using mucoadhesive polymers.
Other ingredients were used to improve palatability of
the formulations. The antacid jellies were also
evaluated for appearance, pH, rheology and taste and a
comparative evaluation was carried out with marketed
suspension. A novel in-house developed model was
optimized to evaluate in vitro residence.
The concentration of the gelling agents was optimized to
offer product of optimum viscosity so as to remain in
contact with the oesophagus for prolonged period of
time. All the formulations exhibited optimum
physicochemical properties with improved stay and in
vitro residence compared to the marketed suspension.
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