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THE PHARMA REVIEW (JULY - AUGUST 2010)

Design of in Vitro Residence Model for Evaluation of Antacid Jellies in Hiatus Hernia

Pradnya Palekar Shanbhag, Akshay J. Naik, Pravin L. Dhavle, Jogindersingh Paneysar

Abstract
Convenience of administration and patient compliance are gaining significant importance in the design of drug delivery systems. The present work includes formulation of patient friendly antacids jellies to treat oesophageal reflux in hiatus hernia and secondly design of a novel model for evaluating in vitro residence time of the formulations.
The jelly base was prepared using mucoadhesive polymers. Other ingredients were used to improve palatability of the formulations. The antacid jellies were also evaluated for appearance, pH, rheology and taste and a comparative evaluation was carried out with marketed suspension. A novel in-house developed model was optimized to evaluate in vitro residence.
The concentration of the gelling agents was optimized to offer product of optimum viscosity so as to remain in contact with the oesophagus for prolonged period of time. All the formulations exhibited optimum physicochemical properties with improved stay and in vitro residence compared to the marketed suspension.

 

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