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THE PHARMA REVIEW (JULY - AUGUST 2010)

Pharmacosomes: An Alternative Carrier System for Drug Delivery

N.L. Prasanthi, S.S. Manikiran, N. Rama Rao

Abstract
Various types of vesicular systems such as liposomes, niosomes, transfersomes and pharmacosomes have been developed in the transport and targeting of active agents. Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids, and may exist as ultrafine vesicular, Micellar, or hexagonal aggregates, depending on the chemical structure of drug-lipid complex. This system shows low entrapment efficiency and drug leakage during storage for hydrophilic drugs. Pharmacosomes have some importance in escaping the tedious steps of removing the free from entrapped drug. Similar to other vesicular system pharmacosomes provide an efficient method for delivery of drug directly to the site of infection, leading to reduction of drug toxicity with no adverse effects also reduces the cost of therapy by improved bioavailability of medication, especially in case of poorly soluble drugs. Pharmacosomes are suitable for incorporating both hydrophilic and lipophilic drugs.

 

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