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THE PHARMA REVIEW
(JULY - AUGUST 2010) |
Pharmacosomes: An
Alternative Carrier System for Drug Delivery
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N.L. Prasanthi, S.S.
Manikiran, N. Rama Rao |
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Abstract
Various types of vesicular systems such as liposomes,
niosomes, transfersomes and pharmacosomes have been
developed in the transport and targeting of active
agents. Pharmacosomes are the colloidal dispersions of
drugs covalently bound to lipids, and may exist as
ultrafine vesicular, Micellar, or hexagonal aggregates,
depending on the chemical structure of drug-lipid
complex. This system shows low entrapment efficiency and
drug leakage during storage for hydrophilic drugs.
Pharmacosomes have some importance in escaping the
tedious steps of removing the free from entrapped drug.
Similar to other vesicular system pharmacosomes provide
an efficient method for delivery of drug directly to the
site of infection, leading to reduction of drug toxicity
with no adverse effects also reduces the cost of therapy
by improved bioavailability of medication, especially in
case of poorly soluble drugs. Pharmacosomes are suitable
for incorporating both hydrophilic and lipophilic drugs.
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