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THE PHARMA REVIEW (JULY - AUGUST 2011)

Simultaneous Estimation of Famotidine and Diclofenac Potassium in Combined Tablet Dosage Form by Multicomponent Mode of Analysis

D. R. Chaple*, S.A. Mehta, M.P. Yeole, P. S. Tarte

Abstract
A simple, accurate, precise and economical procedure for simultaneous estimation of famotidine and diclofenac potassium in combined tablet dosage form has been developed. The sampling wavelengths 260 nm, 270 nm, 275 nm, 280 nm and 290 nm were selected. Both the drugs and their mixture obey Beer-Lamberts law at selected wavelength at given concentration range. The absorbances are practically additivity at the selected wavelengths. The results of analysis were validated statistically and by recovery studies.
Introduction
The aim of this paper was to explore the possibility of using technique of simultaneous equation method for quantifying famotidine1-6 and diclofenac7-12 simultaneously in their mixture form. The advantage of this proposed method is that no separation is required. This paper represents a simple, rapid, economical method for the analysis of two components in tablet formulation and act as convenient alternative to HPLC method.
Material and method
The absorption spectra of the solutions were recorded over the range of 200-400 nm keeping the solutions in 1 cm quartz cells using Shimadzu UV/Visible double beam spectrophotometer model UV 1601. Gift samples of pure famotidine (FMN) and diclofenac potassium (DICP) were procured from Dr. Reddy’s Lab. and Wama pharma. Combined FMN and DICP tablets (Dicka-F containing FMN -20 mg and DICP -50 mg and manufactured by Biogenitics Drugs Pvt. Ltd.) were purchased from a local pharmacy. Analytical reagent grade N, N-dimethyl formamide (DMF), NaOH solution (0.1 N) in distilled water was used as solvent. Accurately weighed quantities of FAM (10 mg) and DICP (25 mg) were transferred in 100 mL volumetric flask and volume was adjusted up to 100 mL with DMF. The above solution was appropriately diluted with DMF to get final concentration in the range of FAM (4 g/mL) and DICP (10 g/mL). The selected five wavelengths (i.e 260nm, 270nm, 275 nm, 280nm and 290nm) were adjusted on the multicomponent mode of spectrophotometer. The concentrations of both the components of each of five mixed standards were entered in it. Then all the mixed standard solutions were scanned over the range 250 nm to 300 nm in 1cm cell against blank. The concentration of each of the component was obtained by analysis of spectral data of the sample solution with reference to that of six mixed standard, directly in terms of g/mL.

 

 

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