BRINGING YOU INFORMATION.  PROVIDING YOU A PLATFORM.

 

 
THE PHARMA REVIEW (JULY - AUGUST 2011)

The Synthesis, Characterization and Evaluation of Some Novel Quinolone Derivatives

Vikrant Verma

Abstract
Quinolones are well known for their antibacterial properties, differently substituted quinolones have been synthesized in the present research work by cyclization of parasubstituted aniline with diethylethoxymethylene malonate followed by alkaline hydrolysis and evaluated to explore the effect of substitution at different sites on the antibacterial activity. The present study was done to exploring the effect of different subtituents at 6 and 8 position on the antibacterial activity. It was found that by substitution at 6 and 8 position there is improvement in antibacterial activity. The compound B was found to be most effective against E.coli and b.subtillus in comparison to the standard drug at concentration 2g/ml, 8g/ml. The compound A was found to be least effective against E.coli and b.subtillus in comparison to standard drug .Antibacterial activity was evaluated by finding minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution method.
Introduction
Quinolones comprise a relatively large, growing and most interesting group of antibacterial drugs which have made a major impact on the field of antimicrobial chemotherapy, particularly in the past few decades. This is because they potentially offer many of the attributes of an ideal antibiotic, combining high potency, a broad spectrum of activity, good bioavailability, oral and intravenous formulations, high serum levels, a large volume of distribution indicating concentration in tissues and a potentially low incidence of side-effects. The importance of the quinolone as a nucleus with medicinal properties is well established, since many decades. Literature survey reveals that the heterocyclic quinolone nucleus has been consistently rewarded as a promising molecule because of its broad spectrum pharmacological activities like antibacterial1 , FMS Kinase Inhibitor2, antitumor3, anti HIV4 etc.
Most of the solvents used were of LR grade. Chemicals used were of LR grade and obtained from Oualigens fine chemicals, Rankem RFCL Ltd. New Delhi , Central Drug House New delhi and Sigma Aldrich, USA etc. The solvents used through out the experiment for running TLC were Dicholoromethane:Methanol in the ratio of 98:2. All the reactions were monitored by thin layer chromatography (tlc) plates coated with silica gel from Qualigens (India). Plates were visualized by iodine vapours . The plates were also visualized in UV light. Melting points of compounds were measured by capillary fusion technique.

 

 

Go to Content Index Page

PHARMA REVIEW - ARTICLES ARCHIVE ( COMPLETE LIST)

 

The above content is an abstract only. For the full Article please contact:
KONGPOSH Publications Pvt. Ltd.
ICS House, C-19, Commercial Complex, SDA, Opp. IIT Gate, New Delhi, India -110016
Tel.: 26855839, 9811195411
Email: kongposhpub@gmail.com, Website: http://www.kppub.com

 
 
 
 

Copyright KONGPOSH PUBLICATIONS Pvt. Ltd.