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THE PHARMA REVIEW (JULY - AUGUST 2012)

Evaluation of Anti-Inflammatory Activity of Hybanthus Enneaspermus Muell Leaves

Subhangkar Nandy1, Bodhisattwa Chakraborty2 and Paoulomi Chatterjee3

Introduction:
 
Inflammation is a tissue reaction to infection, irritation or foreign substance. It is a part of the host defense mechanism but when it becomes great it is a hopeless condition. Aging is also considered to be an inflammatory response. There are several tissue factors or mechanisms that are known to be involved in the inflammatory reactions such as release of histamine, bradykinin and postaglandins. The development of non steroidal anti inflammatory agents in recent years has contributed a lot in not only overcoming the human suffering such as arthritis but also has helped in understanding the tissue mechanisms of inflammations. The inflammation reaction is readily produced in rats in the form of paw oedema with the help of irritants. Substances such as carrageenan, formalin, bradykinin, histamine, 5-hydroxytryptamine, mustard, or egg white when injected in the dorsum of the foot of rats they produce acute paw oedema within a few minutes of the injection. Carrageenan- induced paw oedema is the most commonly used method in experimental pharmacology1-3. Carrageenan is a sulphated polysaccharide obtained from seaweed (Rhodophyceae), and by causing the release of histamine, 5-HT, bradykinin and prostaglandins it produces inflammation and oedema. Natural products in general and medicinal plants in particular, are believed to be an important source of new chemical substances with potential therapeutic effi cacy4. The main treatments used to prevent or minimize the progression of inflammation include non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, but they are known to have deleterious side effects5. Traditional medicine has been used to address human health demands and nowadays it could be considered as the most important source of new anti-inflammatory compounds6.

 

 

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