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THE PHARMA REVIEW (JULY - AUGUST 2012)

Production and Evaluation of Diltiazem Hydrochloride Pellets by Pan Coating Process

S.Vidyadhara1, M.Bhanu Prasad2, RLC Sasidhar1, S Sivaprasad1

Introduction:
 
Multiparticulate dosage forms (MPDF) are receiving a immense attention as alternative drug delivery system for oral drug delivery even though single unit dosage forms have been widely used for decades. The most commonly used pharmaceutical solid dosage forms today include granules, pellets, tablets and capsules, out of which tablets being the most popular dosage form, accounting for 70% of all ethical pharmaceutical preparations produced. The most increasingly interesting area in the development of MPDF’S is incorporation into tablets instead of hard gelatin capsules in order to make it more economical to the consumers and gaining more attention currently. The present research work focuses on the pelletized form of multiple units, they are prepared by process called Pelletization which is referred to as a size enlargement process and the final product obtained is called pellets. Pellets provide a reduction in the dosage regimen and gastrointestinal irritation moreover controlling the drug release and increasing the absorption of the active ingredient. Also one of the advantageous properties of the pellet formulations is being good candidates for the delivery of the drug substances due to minimizing the dose dumping effect. The reproducibility of the release characteristics from pellet formulations is also much better with respect to the single-unit dosage forms. They are suitable systems for film coating with respect to the low surface area-volume ratios. Also, resistance to external factors such as moisture, air and light are the most advantageous properties of these dosage forms1-4.

 

 

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