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THE PHARMA REVIEW (JULY AUGUST 2014)

Development and Validation of Analytical Method for Estimation of Glucosamine and Diacerein in Tablet Dosage Form by Spectrophotometry

Varsha Bhoir, Viraj Hibare & Mrinalini C. Damle

Introduction: Glucosamine is an amino sugar, a prominent precursor in the biochemical synthesis of glycolated proteins and lipids, commonly used in the treatment of osteoarthritis. It is chemically (3R, 4R, 5S, 6R)-3-Amino-6-(hydroxymethoxy) oxane-2, 4, 5-triol1. Diacerein (DCR) [4, 5-Bis (acetyloxy)-9, 10-dihydro-9, 10-dioxo-2-anthracenecarboxylic acid. Diacerein directly inhibits IL-1 Synthesis and release in vitro and down modulate IL-1 induced activities and has been shown to possess disease modifying effect in experimental models of Osteoarthritis and in human subject with finger joint and knee Osteoarthritis. Hence, by inhibiting IL-1 Diacerein retards all pathological process initiating in Osteoarthritis (OA)2. 

 

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