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THE PHARMA REVIEW (JULY AUGUST 2016)

An Overview on Neurodegenerative Diseases and Possible Leads from Natural Products

Anindita Kundu1, Vivekananda Mandal2 & Subhash C. Mandal**

Introduction: Naturally occurring phytochemicals offer a safe approach to protect against a first-line treatment of several types of neurodegenerative diseases and also is an alternative to other conventional treatment methods. Even though the prevailing view in the field of pharmacology is to slow or stop neurodegenerative disease progression, but a gap still exists between pharmacological and pharmacognostical approaches to the treatment and cure of the various neurodegenerative diseases. In neurodegenerative disease states the systems, organs, and cells are under oxidative stress often suffer from unbalanced ionic gradients and are subjected to the protein interference both inside and outside the signaling pathways which eventually make the cells, organs, and systems vulnerable to injury. Although dietary phytochemicals and the synthetic drugs with nerve growth factor (NGF) potentiation effects are clearly effective in different neuron cell models, many issues need to be addressed before clinical trials. 

 

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