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THE PHARMA REVIEW (JULY AUGUST 2016)

Chemometrics - Assisted UV Spectrophotometric Method for Determination of Ofloxacin and Ornidazole in Pharmaceutical Formulation

Dr. Santosh Gandhi* & Shreeyash Tapale

Introduction: This presented work is based on application of two multivariate calibration methods for simultaneous UV-Vis spectrophotometric determination of active substances in combined pharmaceutical formulation composed of Ofloxacin (OFLOX) and Ornidazole (ONZ). The methods used were Principal Component Regression (PCR) and Partial Least Square (PLS). The Spectra of OFLOX and ONZ were recorded at concentrations within their linear ranges 2.0-12.0 μg/ml and 5.0-30.0 μg/ml, respectively. 36 set of mixtures were used for calibration and 12 set of mixtures were used for validation in the wavelength range of 220 to 350 nm with the wavelengths intervals λ= 0.5 nm in methanol. The methods were validated as per International Conference on Harmonization Q2 (R1) (ICH) guidelines. These methods were successfully applied for determination of drugs in pharmaceutical formulation (tablet) with no interference of the excipients as indicated by the recovery study results. The proposed methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control as well as in process control of drugs and formulation. 

 

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