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THE PHARMA REVIEW (MAR 2010)

Critical Role of Excipients in Pharmaceutical Formulations - A Look Into The Crystal Ball

Y. H. Gharpure

Introduction
“Quality means freedom from deficiencies – freedom from errors that require doing work again (rework) or that results in field failures, customer dissatisfaction, customer claims.” Joseph M. Duran, Father of QA

“Although drugs are responsible for therapeutic activity, it is a medicine and not a drug which a patient receives in the treatment of an illness. The difference separating a medicine from a drug is the presence of excipients and these may lead to changes in the biopharmaceutical performance of the system”


History of Excipients
Although important pharmaceutical industry has been using excipients, developed over the last century or little more, excipients per se have been used since ancient time. Given below is evolution of excipients:

 

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