Influence of Processing Conditions in Mouth Dissolve Tablets of Paracetamol

Abstract
The present study focuses on the development of mouth dissolve system of Paracetamol designed as tablets using three techniques viz., effervescent agents, superdisintegrant and combination of effervescent agents and superdisintegrant and the study of influence of these techniques on the in vitro dispersion timeof the tablets. Paracetamol an antipyretic drug was chosen as the model drug candidate with dose 125 mg. Effervescent agents like citric acid, tartaric acid and sodium bicarbonate and superdsintegrant like sodium starch glycolate were used. The developed mouth dissolve tablets were evaluated for standard tablet properties, in vivo dispersion time in human volunteers and in vitro dispersion time was determined by an in–house developed method. A good correlation was obtained between the in vitro and in vivo dispersion times for the developed Paracetamol mouth dissolve tablet
 
Introduction
Solid dosage forms that dissolve rapidly in oral cavity without administration of water are categoriesd as mouth dissolve tablets. Such tablets dissolve rapidly in mouth due to the presence of saliva.
Many paediatric and gerartric patients find it difficult to swallow solid dosage forms. A difficulty in swallowing tablets or capsules is also a common problem among bedridden patients. Mouth dissolve tablets are indicated not only for people having difficulty in swallowing but also ideal for unfavorable conditions of administration where water is not available.
Mouth dissolve tablets have the ability to provide liquid medication in solid form with improved stability and require no chewing or administration of water hence show improved patient compliance.1,2
Mouth dissolve tablets are also known as fast dissolving, rapid –dissolve, rapimelt, fast melts, porous tablets, Orosolv etc.3,4
The aim of present work was to design and develop mouth dissolve system of Paracetamol5,6 as tablets using three techniques viz., effervescent agents, superdisintegrant and combination of effervescent agents and superdisintegrant. The objective of the study was to design mouth dissolve tablets of Paracetamol, to compare the influence of the three techniques on the in vitro dispersion time and to obtain a good correlation between the in vivo dispersion time and in vitro dispersion time of the tablets.

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