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THE PHARMA REVIEW (MARCH - APRIL 2011)

Opportunities and Challenges in Development of Plant Based Therapies

Anantha Naik Nagappa1 *, Inder K Makhija2, Akunuri Praneetha2 and Meenakshi Shripat2

Abstract: The diversity of plant based therapies is not only astonishing but are also getting popular. In this article, the safety, clinical efficacy and market potential of plant based medicinal products are discussed. A plant based product is either a formulation of crude drugs or extracts obtained out of crude drugs. It is grossly believed that the plant based remedies are either effective or not but seldom toxic. The traditional system of medicines dating ancient civilizations are the time tested evidence for the safety. Despite of all these things, the herbal therapies are challenged regarding their safety and efficacy as well. It is high time to decide upon the issues and efficacy of these products. In line with modern synthetic active pharmaceutical ingredients. However it is impractical to draw line in terms of synthetic products due to the fact, herbal medicines compose variety of phytochemicals having diverse biological effects. Despite the drawbacks some clinical trials are reported in the literature which attempts to obtain proof for safety and efficacy, trends in clinical trials of plant based products is discussed here.
Introduction
Plant based products, as a evidence of efficacy, have great promising role and it is gratifying to note that the World health organization (WHO) have shown an abiding interest in plant-derived product. According to the WHO, because of poverty and poor accessibility to modern medicine, approx 65-80% of the world’s population, which lives in developing countries, still depends on plants based therapies for primary health care1. Humans are dependent on plant-based therapies for management of health, for example the ancient system of medicines Ayurveda, Yoga, Unani, Siddha, Homeopathy and Naturopathy. The household remedies and grandmother remedies, which are composed of regular ingredients of kitchen and are home-based medicines, are used as over the counter medicines2. The major drawbacks of modern medicines is due to its variety of side effects endangers the safety of patient quite often. Moreover medicines used in chronic diseases are seldom curative and need to be taken life long. Although herbal therapies are no match compare to modern herbal therapies are medicines but still they are popular due to the fact that they are mild and do not cause injuries as synthetic drugs. This may be the reason for increasing trend in consumption of drugs3. It was estimated last year of $ 60 billion of.

 

 

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