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THE PHARMA REVIEW (MARCH APRIL 2016)

Development and Validation of RP-HPLC Method for The Simultaneous Determination of Montelukast Sodium
and Levocetirizine Dihydrochloride in Pharmaceutical Dosage Forms

Varun Rathi*, Prof.Vijender Singh, Navneet Verma & Dharmendra Kumar

Introduction: A reverse phase high performance liquid chromatographic (RP-HPLC) method have been developed and validated for the simultaneous determination of Montelukast sodium and Levocetirizine dihydrochloride in pharmaceutical dosage forms. The separation was achieved by using RPC-8 column (250 mm x 4.0 mm, 5μm). The flow rate of 1.2 ml/min was set for the isocratic elution with the mixture of 0.05M Potassium dihydrogen phosphate buffer of pH 7.0 (adjusted with 5% solution of H3PO4/ KOH) and Methanol in the ratio 25:75 v/v was used as mobile phase and detection was carried out at 230nm with a load of 10μl. The retention time of Levocetirizine and Montelukast were found to be 2.32 and 3.26min respectively (Figure-3). Results of the analysis were validated statistically and by recovery studies (Table-V).

 

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