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THE PHARMA REVIEW (MARCH 2009)

Anti Obesity Drugs

N. Ramarao, Prasanthi N.L, Lakshmi. K, Jeevani. P

Abstract: Obesity is an abnormal growth of the adipose tissue due to enlargement of fat cell size or increase in fat cell number or both. It is now the most common nutritional disorder. 97 million adults in this country are obese, representing 31.3 percent of men and 34.7 percent of women. Treatment of obesity accounts for 5 to 7 percent of total health care costs annually. The causes of obesity are complex, but a combination of behavioral, genetic, hormonal, economic and environmental factors play important role in origin and progression of disease. The current paper review classical and newer anti obesity drugs, obesity surgery and natural ingredients as anti-obesity drugs.
 
Introduction
Obesity is a state of excess adipose tissue mass. It may be defined as an abnormal growth of the adipose tissue due to enlargement of fat cell size ( hypertrophic) or increase in fat cell number (hyper plastic obesity) or both. It is now the most common nutritional disorder in western industrialized countries, body mass index (BMI) of 25 to 29.9 is considered as overweight. BMI of 30 or greater is considered as obese. Increased BMI is linked with a greater risk of coronary heart disease, hypertension, hyperlipidaemia, non insulin dependent diabetes mellitus and certain cancers. The causes of obesity are complex, but a combination of behavioral, genetic, hormonal, economic and environmental factors play important role in origin and progression of disease.

The World Health Organization has formulated an index for defining obesity, known as the body mass index (BMI), it is based on the patient's height in meters and weight in kilograms: BMI = weight in kilograms / height in meters2 (Figure 1). This classification works for all patients except those at the extremes of height or muscle mass, where body proportions affect the calculation.4 

 

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