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THE PHARMA REVIEW (MARCH 2009)

Diuretic Activity of Ethanolic Extract of Ervatamia Heyneana Roots

Hemlata Sati, Himanshu Joshi, Arub B. Joshi

Abstract: The diuretic activity of the ethanolic extract of the roots of E.heyneana was evaluated by determination of urine volume, electrolyte concentration and diuretic potency in male Wistar rats. Oral administration of the ethanolic extract of the roots of E. heyneana at doses of 100, 200 and 400 mg/kg body weight showed significant diuretic activity in rats. Preliminary phytochemical screening of the ethanolic extract of the roots of E. heyneana revealed the presence of alkaloids, sterols, triterpenoids, resins and flavonoids.

Introduction
Ervatamia heyneana (Wall) (syn: Tabernaemontana heyneana) is a shrub or small tree belonging to the family apocynaceae. It is found distributed in open forests of Konkan, North Kanara, Western Ghats, in Malabar and Travancore up to on altitude of 3000 ft. It is being used traditionally by local population as remedy for various ailments. Many indole alkaloids, sterols, triterpenoids have been reported from latex , root bark, roots, seeds, and stem bark of the plant E. heyneana.

Anti-cancer activity of the extract of the root, stem and leaf have been reported from E. heyneana. In view of the fact that there is no systematic study on the diuretic effect of the root of E. heyneana, the present study on the diuretic effect of the ethanolic extract of the roots of E. heyneana has been conducted.

Material And Methods

 
Plant material
The roots of E. heyneana were collected from Mangalore, Karnataka, India during April-2005. It was authenticated by Prof. Dr. Gopalakrishna Bhat, Department of Botany, Poornaprajna College, Udupi, Karnataka, India. A Voucher specimen No.101 b is deposited in the herbarium of our institute.

Preparation of extract
The powder roots were Soxhlet extracted with ethanol. The extract, on removal of solvent in vacuum gave a reddish brown semisolid residue (yield: 9.8%w/w). 

 

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