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Abstract: The diuretic activity of the ethanolic
extract of the roots of E.heyneana was evaluated by
determination of urine volume, electrolyte concentration
and diuretic potency in male Wistar rats. Oral
administration of the ethanolic extract of the roots of
E. heyneana at doses of 100, 200 and 400 mg/kg body
weight showed significant diuretic activity in rats.
Preliminary phytochemical screening of the ethanolic
extract of the roots of E. heyneana revealed the
presence of alkaloids, sterols, triterpenoids, resins
and flavonoids.
Introduction
Ervatamia heyneana (Wall) (syn: Tabernaemontana
heyneana) is a shrub or small tree belonging to the
family apocynaceae. It is found distributed in open
forests of Konkan, North Kanara, Western Ghats, in
Malabar and Travancore up to on altitude of 3000 ft. It
is being used traditionally by local population as
remedy for various ailments. Many indole alkaloids,
sterols, triterpenoids have been reported from latex ,
root bark, roots, seeds, and stem bark of the plant E.
heyneana.
Anti-cancer activity of the extract of the root, stem
and leaf have been reported from E. heyneana. In view of
the fact that there is no systematic study on the
diuretic effect of the root of E. heyneana, the present
study on the diuretic effect of the ethanolic extract of
the roots of E. heyneana has been conducted.
Material And Methods
Plant material
The roots of E. heyneana were collected from Mangalore,
Karnataka, India during April-2005. It was authenticated
by Prof. Dr. Gopalakrishna Bhat, Department of Botany,
Poornaprajna College, Udupi, Karnataka, India. A Voucher
specimen No.101 b is deposited in the herbarium of our
institute.
Preparation of extract
The powder roots were Soxhlet extracted with ethanol.
The extract, on removal of solvent in vacuum gave a
reddish brown semisolid residue (yield: 9.8%w/w).
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