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Abstract: There are numerous strategies that can
be applied when developing combination products with
soluble compounds. However, new strategies will have to
be used when considering combinations with soluble and
insoluble compounds. INNERCAP Technologies, Inc., a drug
delivery company, offers an advanced patent pending
multi-phased, multi-compartmentalized capsular-based
delivery system. The system can be used to enhance the
value and benefits of pharmaceutical and
biopharmaceutical products. It is a very effective way
to deliver multiple active chemical compounds in
different physical phases with controlled release
profiles. Each compartment is sealed to prevent the
medicaments from escaping and coming into contact with
one another. This approach maximizes bioavailability
and, at the same time, addresses patient compliance
problems
Introduction
Combination pharmaceutical products are defined as being
able to treat the same disease state, multiple disease
states, or counteract the negative side-effects.
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Additivity’ is combining two or more drugs with
complementary modes of action to gain the desired
therapeutic effect without the side-effects;
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Potentiation’ is the synergistic effect on drug A by
adding a dose of drug B without a therapeutic
effect;
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Cancellation’ is when effects of one drug are nullified
by the addition of a second.
A
combination product may contain pharmaceuticals,
biopharmaceuticals, or nutraceuticals. They can also
incorporate several, different controlled-release
profiles, such as immediate, pulse, chronotherapy,
targeted and sustained.Cocktail drugs means a number of
drugs face the fear of extinction as they fall prey to
resistance. Combination drugs counter this problem and
offer a higher level of efficacy as well.
Combination products are composed of two or more
regulated components – drugs, medical devices, or
biologics, combined through physical or chemical means.
These include drug coated devices, drugs packaged with
delivery devices in medical kits, and drugs and devices
packaged separately but intended to be used
together.Combination products are also being marketed or
developed for orthopedics (eg, protein-coated implants
to encourage bone regeneration), cancer (eg, a tumor
ablation system), infection control (surgical mesh with
antibiotic coating), and diabetes care (integrated
glucose meter and insulin pump). Future combination
product applications are expected to include
implantable, closed loop insulin pumps, steroid-eluting
electrodes, or even novel “physical solutions,” such as
drug-coated surgical screws, catheters, sutures, and
wire.
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