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THE PHARMA REVIEW (MAY 2010)

Dried Blood Spot Analysis by TLC-MS Interface

Akshay Charegaonkar

Introduction
Mass Spectroscopy (MS) is the analytical detector of choice for many separation techniques including High Pressure Liquid Chromatography (HPLC) and Gas Chromatography (GC). MS is a mature and sophisticated technology and as a result, many reference spectrum libraries of molecules are readily available. The Camag TLC-MS interface is a new instrument for eluting separated fractions on a TLC plate or other planar surface into MS. The elution head of the instrument under gas pressure forms a tight seal around the spot/band to be extracted, after which the eluting solvent is pumped at one end of the spot and extracted at the opposite end. The solvent eluted at the other end contains dissolved components from the dried blood spot. This extraction solvent is fed directly into an MS for analysis. The TLC-MS interface is designed to be easy to connect to an MS instrument from any leading manufacturer.

 

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