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THE PHARMA REVIEW (MAY 2010)

Simultaneous Estimation of Olmesartan Medoxomil and Hydrochlorothiazide in Combined Tablet Dosage Form by Multicomponent Mode of Analysis

V. S. Banode, P. B. Khedekar, P. S. Tarte

Abstract
A simple, accurate, precise and economical procedure for simultaneous estimation of Olmesartan medoxomil and Hydrochlorothiazide in two component tablet dosage form has been developed for the quantitative estimation. The method is based upon determination of Olmesartan medoxomil at 256.5 nm and Hydrochlorothiazide at 271 nm, in methanol by the g multicomponat mode of analysis of UV spectrophotometer. Olmesartan medoxomil show Beer’s law in the concentration rang of 0-50 g/ml while Hydrochlorothiazide in the range 0-30 g/ml. For both the drugs their absorbances are practically additivity at both the wavelengths. The method was validated statistically. Recovery study was performed to confirm the accuracy of the method.

 

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