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THE PHARMA REVIEW (MAY - JUNE 2012)

Review on Stability Indicating Methods of Ranitidine Hydrochloride

Vivekkumar K. Redasani, Vaibhav L. Patil, Vijay K. Patil, Sanjay J. Surana

Abstract: Ranitidine hydrochloride exists in different formulations such as tablet, oral liquids and injectables. From these the most used formulation is syrup, due to its ease and safety, hence needs to find out stable method for the same. Most of the stability indicating methods was reported for its determination in these formulations. So the purpose is to study the most appropriate method indicating stability of ranitidine. Stability was determined by various techniques like high performance liquid chromatography (HPLC), thin layer chromatography (TLC), potentiometry, polarographic, voltametric, spectrophotometric, near infra-red reflectance spectrometric. The purpose of present review is to describe the stability indicating methods for ranitidine and to study various parameters. These methods were found to be stable, validated and applicable for qualitative and quantitative analysis as well.
 
Introduction:
Ranitidine hydrochloride (C13H22N4O3S.HCl) [Fig. 1], [RNC] a H2 receptor antagonist, is used in treatment and maintenance of gastric and duodenal ulcers, gastro-oesophageal reflux disease and stress ulcer. It is widely used in conditions in which it is profitable to suppress gastric acid secretion. It was introduced subsequent to cimetidine as a non-imidazole (furan ring) H2 blocker. It is about 5 times more potent than cimetidine. Though its pharmacokinetic profile and t1/2 of 2-3 hr is similar to cimetidine, but a longer duration of action with greater than 24 hr acid suppression ability supports its higher potency.

 

 

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