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THE PHARMA REVIEW (MAY - JUNE 2012)

Studying of The Antifungal Properties of The Liposomal Terbinafine and Benzoyil Peroxide Concerning of Candіda spp BIOFILM

Ivanova N.N., Mavrov G.I

Abstract: As the result of the minimum inhibitory concentration (MIC) determination of the liposomal preparations concerning fungal infections caused by Candіda albіcans it has been found that the liposomes received on the basis of egg lecithin and terbinafine or benzoyil peroxide are more effective at increase in concentration of lecithin. The antifungal activity of the liposomal terbinafine and liposomal benzoyil peroxide concerning the biofilms Candіda albіcans was higher than terbinafine and benzoyil peroxide in 8- 20 times depending on structure and the charge of liposomes. The action of liposomal terbinafine and benzoyil peroxide on the Candіda albіcans biofilms led to the inhibition of gene МЕТ3 expression and to the biofilms formation process.

Introduction:
Antibiotic treatment and mechanisms of of natural protection of a macroorganism against infections at times inconsistent, which is accompanied by the development of biofilms. Candіda albіcans (C.albіcans) is one of the most dangerous dimorphic fungi pathogenic to humans. The process for the existence of microorganisms in a biofilms is a big problem in medical practice, due to the fact that the composition of biofilms fungi are more resistant to antibiotics. By way of the example of C.albіcans it was shown that the inhibition of metabolic activity in biofilms is necessary in the 30-2000 times higher concentrations of antimycotics than their minimum inhibitory concentration for planktonic cells.
The formation of biofilms is largely associated with the processes of fixation of microorganisms on a solid surface or binding to each other. These complex processes are due to activation of a number of biochemical processes and are accompanied by changes in expression of many genes, which reflect changes in vital processes during the formation of complex multicellular associations.

 

 

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