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THE PHARMA REVIEW (MAY - JUNE 2013)

Effect of O. sanctum (L) Leaf Extract on Testicular Tissue Ascorbic Acid in Arsenite Exposed Albino Rats

Mahto P.K1, Dubey A.K1, Parashar P1, Singh H.R2, Jha S.K.2

Introduction
The use of plants as a source of herbal medicines with different pharmacokinetic and pharmacodynamic ingredients draw the attention of scientists for their therapeutic uses. The three Indian traditional systems of medicines (Ayuveda, Siddha and Unani) have identified more than 1500 medicinal plants of which nearly 700 are commonly used (Agrawal and Raju, 2006). WHO (2000) estimated that 70-80% of the world population especially in developing countries relies on plant drugs for their primary health care. Arsenic, a worldwide environmental contaminant of paramount toxicological significance, can be found in soil, water and air as a result of both natural and anthropogenic activities. Generally, environmental exposure to inorganic arsenic occur through the consumption of drinking water drawn from the ground water sources. Ground water contamination with arsenic has been reported from more than 30 countries in the world (Chakrabarti et al.,2002). According to the report of Nickson (2007), the problem of arsenic contamination in ground water spreading to different states of India, viz. Bihar, U.P., Jharkhand, Assam, Chhatisgarh and Andhra Pradesh. Thus in our polluted world, high level of toxicity in the body are an underlying cause of ill health.

 

 

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