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THE PHARMA REVIEW (MAY - JUNE 2013)

Numerical Simulations for Continuous Manufacturing of Active Pharmaceutical Ingredients

Sabine Goodwin1 & Dr. Kristian Debus2

Introduction
With unprecedented economic pressures and increased global competition, pharmaceutical manufacturing companies are continuously looking to gain a competitive advantage through improving the efficiency of their processes and the quality of their products. Traditional manufacturing processes, which are batch processes, are no longer sustainable and there is no question that continuous manufacturing is the clear path forward towards leaner processes. Multi-physics numerical simulation is emerging as game-changing technology to help continuous manufacturing for Active Pharmaceutical Ingredients (APIs) become a reality through virtual prototyping, optimization and modeling of the complete system.

 

 

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