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THE PHARMA REVIEW (MAY JUNE 2015)

Development and Validation of Stability Indicating HPTLC Method for Estimation of Losartan Potassium

Santosh V. Gandhi, Trupti R. Phalke, Ashwini M. Gaikwad & Prashant S. Mittal

Introduction: Losartan Potassium, chemically is 2-butyl-4-chloro-1-({4-[2-(2H-1, 2, 3, 4-tetrazol-5-yl) phenyl] phenyl} methyl)-1H1Himidazol- 5-yl]methanol, is antihypertensive and act by inhibiting Angiotensin II receptor. Lactim-form of this compound upon chlorination with phosphorus oxychloride gives the corresponding derivative which play a crucial role in the treatment1. It is official in Indian pharmacopoeia (IP), British Pharmacopoeia (BP) and United State Pharmacopoeia (USP). It is estimated by potentiometric titration and chromatographic method as per IP, BP and USP2-4 

 

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