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THE PHARMA REVIEW (MAY – JUNE 2018)

Photosensitive Liposomes: New Frontiers in Drug Delivery Systems

Neeraj Kumar Sharma1 & Vimal Kumar2

Introduction: The word liposome derives from two Greek words: lipo ("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid. A liposome has an aqueous solution core surrounded by a hydrophobic membrane, in the form of a lipid bilayer; hydrophilic solutes dissolved in the core cannot readily pass through the bilayer. Hydrophobic chemicals associate with the bilayer. A liposome can be hence loaded with hydrophobic and/or hydrophilic molecules. . Liposomes originated in the work of Alec D Bangham and coworkers (Bangham and Horne, 1964) at the Babraham Institute in Cambridge. While studying phospholipids with the help of electron microscope, they discovered bilayer lipid structure by adding negative stain to dry phospholipid. Initially they termed these materials as ‘smecticmesophase system’. Later on Gerald Weissmann renamed them as liposomes.

 

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