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THE PHARMA REVIEW (MAY JUNE 2018)

Vital Drug Delivery Nanoconstructs for Enhanced Oral Bioavailability of Bioactives

Bhupinder Singh1,2*, Sarwar Beg1,3, Sumant Saini1, Ripandeep Kaur2 & Teenu1

Introduction: With the advent of nanotechnology, the whole world is experiencing unprecedented renaissance in relation to disease, diagnosis, and drugs. The domain of nanomedicine has brought forth several promising nanoconstructs as drug delivery technologies through diverse routes of administration. Oral drug delivery systems (DDS), nevertheless, find the widest acceptance among patients and manufacturers for treating diverse pathological ailments. Development of such products poses major challenges to pharmaceutical development scientists, as more than one-half of new molecular entities exhibit poor and inconsistent bioavailability. Ostensible causes of these bioavailability issues encompass poor aqueous solubility, extensive hepatic first-pass effect, acid degradation in the presence of gastric fluid, restricted intestinal permeability, gut wall metabolism by cytochrome P450 (CYP450) isozymes and high P-glycoprotein (P-gp) efflux (Figure 1).

 

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