Abstract: Fungal infections like tinea, cutaneous candidiasis and seborrhoeic dermatitis is always a worry and uneasiness to the suffering patients; hence the drug selected in the present study is Ketoconazole which has broad spectrum antifungal activity and belongs to azole class. The preparation and study of medicated paper soap strips was carried out experiments in two phases. Phase-I Studies optimization, which is done for water absorption capacity of paper by determining the parameters like, weight gain, thickness, size & shape, foam test and stability studies. From these parameters best soap, concentration of liquid soap solution and paper is screened out. Phase-II Studies involves incorporation of drug in the best liquid soap solution and paper which were chosen from Phase-I Studies. The incorporation of drug in medicated paper soap strip was achieved by Emulsification technique and application of soap solution over paper was achieved by dipping technique and characterized for thickness, weight, foam test, stability studies, drug content uniformity, FTIR, in vitro drug release studies which were carried out in 0.1N HCl media using prehydrated cellophane membrane for 30 mins. The result indicated that 39.39% drug release in 30 mins. The primary skin irritation studies carried out on guinea pigs, showed no sensitization and edema on skin after 72 hours of application. The microbial studies indicated the drug action through zone of inhibition. The results of present study revealed that the prepared medicated paper soap strips of Ketoconazole is economic, convenient, gives good foam on application, uniform drug content and no skin irritation on animals.
Introduction: Presence of thick foam on the infected part causes hydration of stratum corneum for better permeation of drug. Fungal infections are contagious, spread from person to person. Close contact or sharing a comb or hairbrush with someone who has tinea can spread the fungus from one person to another. Because fungi need a warm, dark, and humid place to grow, public showers, pools, locker rooms, and even the warmth of shoes and socks can give fungi the perfect opportunity to strike. They can be controlled in their initial stage by proper medications. For this purpose there are many topical drug delivery systems available including medicated soap bars and shampoos etc. Their disadvantages being their economy, wastage, recurrence on reuse, no accurate dosage, formation of foam etc. hence the present work is designed to formulate and evaluate medicated soap strips to counter all the above disadvantages.
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