Simultaneous Spectrophotometric Estimation of Paracetamol and
Tramadol Hydrochloride in Solid Dosage Form

Abstract: Two simple, accurate and reproducible spectrophotometric methods, requiring no prior separation have been developed for simultaneous estimation of tramadol and paracetamol in combined dosage form. The first method employs formation and solving of simultaneous equations using 217 nm and 248.6 nm as the two wavelengths for forming equation. The second method involved formation of isoabsorptive equation at 224.2 nm (isoabsorptive point) and at 248.6 nm as a wavelength of paracetamol using methanol as solvent. Both the drugs and their mixtures obey Beer-Lambert's law at selected wavelengths at given concentration range. The methods have been validated statistically and by recovery studies.

Introduction: Tramadol is an analgesic agent, not official in any pharmacopoeia, chemically it is Trans-(±)-2-{(dimethylamino) methyl}-1-(3-methoxyphenyl) cyclohexanol hydrochloride. Literature survey revealed a spectrophotometric method1 for its estimation. Several capillary gas chromatographic2 and HPLC3, 4 methods have been reported for its estimation. Paracetamol is an antipyretic agent; chemically it is N-(4-hydroxyphenyl) acetamide. It is officially in I.P.5, B. P.6 and U. S. P.7 The review of literature revealed that no method is as yet reported for the simultaneous estimation of both the drugs in combined dosage form. This paper describes two simple, rapid, accurate and reproducible methods for simultaneous determination of both the drugs in tablet dosage form.

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