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THE PHARMA REVIEW (NOVEMBER 2009)

Antioxidant and Phenolic Content of the Bark of Artocarpus Lakoocha

Anima Pandey, S.P. Bhatnagar

Abstract: Artocarpus lakoocha (Moraceae) is a widely used medicinal plant by tribals of Jharkhand, India for the treatment of many diseases. Using DPPH and Ferric Ion Reducing properties investigated the antioxidant activity of the plant. The present study showed that the methanolic extracts from the bark of A. lakoocha exhibited a strong antioxidant activity. The flavonoids content was 53.2 mg g-1 and phenolic content was 0.360 g/ml. The present study showed that the Methanolic extracts from the bark of Artocarpus lakoocha exhibited a strong antioxidant activity, and presence of Flavonoids and Phenolic content.

Introduction
Phenolic compounds are commonly found in both edible and nonedible plants, and they have been reported to have multiple biological effects, including antioxidant activity. Crude extracts of fruits, herbs, vegetables, cereals, and other plant materials rich in phenolics are increasingly of interest in the food industry because they retard oxidative degradation of lipids and thereby improve the quality and nutritional value of food. The importance of the antioxidant constituents of plant materials in the maintenance of health and protection from coronary heart disease and cancer is also raising interest among scientists, food manufacturers, and consumers as the trend of the future is moving toward functional food with specific health effects. Free radical reactions, especially with participation of oxidative radicals, have been shown to be involved in many biological processes that cause damage to lipids, proteins, membranes and nucleic acids, thus giving rise to a variety of diseases. Reactive oxygen species (ROS) have been recognized as playing an important role in the initiation and/or progression of various diseases such as atherosclerosis, inflammatory injury, and cancer and cardio vascular disease. Thus, recent studies have investigated the potential of plant products to serve as antioxidants against various diseases induced by free radicals. Additionally, it has been determined that the antioxidant effect of plant products is mainly due to phenolic compounds, such as flavonoids, phenolic acids, tannins and phenolic diterpenes.

Artocarpus lakoocha Roxb. (Hindi: Dahu, Barhal, Beng. Dahu, Sans. Lokoocha, Eng.: Monkey Jack) is a large deciduous tree reaching 15-18 m in height with a spreading head. Reviews of the records in both, traditional and scientific literature, indicated that Artocarpus lakoocha Roxb. have many medicinal uses. The bark in powder form is applied to sores to draw out purlement matter. The seed and bark of the plant are reported to be effective in the treatment of stomach and liver disease. The various compounds have been isolated from the plant such as cycloartenone, cycloartenol α- amyrin and leupeol acetate.8 Till date information has been published on this plant Artocarpus lakoocha.

 

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